登上Cell子刊封面，苏州大学揭示儿童脑肿瘤神经母细胞瘤的发育可塑性

Core Viewpoint - Neuroblastoma is the most common extracranial solid tumor in children, characterized by significant developmental plasticity and intratumoral heterogeneity, leading to a 5-year survival rate of less than 50% in high-risk cases [2][8]. Group 1: Research Background - The study published by Professor Wang Jian's team from Suzhou University and Professor Hu Yizhou's team from Karolinska Institute in the journal Developmental Cell explores the developmental plasticity of neuroblastoma through single-cell multi-omics and spatial transcriptomics [2]. - Neuroblastoma originates from neural crest progenitor cells, which can differentiate into various cell types, including sympathetic neurons and chromaffin cells, and is influenced by genetic abnormalities and the tumor microenvironment [8][9]. Group 2: Research Findings - The research identified an intermediate "bridge" cell state crucial for malignant transformation in high-risk neuroblastoma, characterized by extensive epigenetic pre-activation features and potential for multidirectional state transitions [9][10]. - A transcription factor-enhancer gene regulatory network (TF-eGRN) was defined, which characterizes tumor states and is influenced by the specific microenvironment of the bridge/progenitor cell state, promoting mesenchymal characteristics [10].