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瘦身奇效,糖患重获健康!顶级医刊曝光重磅研究:体重降幅与二型糖尿病逆转率惊人相关
GLP1减重宝典·2025-09-15 09:48

Core Insights - A groundbreaking meta-analysis published in The Lancet Diabetes & Endocrinology reveals a strong dose-response relationship between weight loss and diabetes remission in overweight or obese patients with type 2 diabetes [6][9] Summary by Sections Weight Loss and Diabetes Remission - The study found that weight loss is a critical factor in controlling type 2 diabetes and reducing the risk of related complications, providing clear treatment goals and expected outcomes for clinicians and patients [9] - The analysis included 22 high-quality randomized controlled trials, focusing on complete and partial remission metrics [7] Remission Rates - Complete remission was defined as having a hemoglobin A1c level below 6.0% or fasting blood glucose below 5.6 mmol/L without any diabetes medications after one year of intervention [7] - The results showed dramatic differences in complete remission rates based on weight loss: only 0.7% of patients losing less than 10% of their body weight achieved complete remission, while nearly half (49.6%) of those losing 20%-29% achieved it, and an impressive 79.1% of those losing over 30% achieved complete remission [7][8] Partial Remission Rates - Partial remission rates also exhibited a clear upward trend: 5.4% for those losing less than 10%, 48.4% for 10%-19%, 69.3% for 20%-29%, and 89.5% for those losing over 30% [7][8] Statistical Analysis - The study calculated that for every 1% weight loss, the probability of complete remission increases by 2.17%, and the probability of partial remission increases by 2.74% [8] - Notably, no significant associations were found between remission outcomes and factors such as age, gender, race, disease duration, baseline body mass index, hemoglobin A1c levels, insulin use, or weight loss intervention methods [8]