tau的结构·修饰·致病：从基础功能到神经退行性疾病的诊断与治疗突破

Core Insights - The article emphasizes the critical role of tau protein in neurodegenerative diseases and its potential as a therapeutic target, highlighting its dual role as a protector of neurons and a key player in disease progression [3][4]. Group 1: Background and Importance - Tau protein is a key microtubule-associated protein in the central nervous system, essential for maintaining neuronal structure and axonal transport [3]. - Abnormal post-translational modifications of tau, such as hyperphosphorylation, lead to its detachment from microtubules and aggregation into neurofibrillary tangles, a hallmark of Alzheimer's disease and other neurodegenerative disorders [3]. - Understanding tau's pathogenic mechanisms and exploring tau-related biomarkers and therapeutic strategies are crucial for advancing both basic research and clinical trials [3]. Group 2: Lecture Details - The upcoming online lecture titled "Tau Structure, Modification, and Pathogenesis: Breakthroughs in Diagnosis and Treatment of Neurodegenerative Diseases" will focus on tau protein, discussing its structural features, biological functions, and its role in Alzheimer's disease [4][9]. - Di Zhu, a Senior Product Manager at Sino Biological US Inc., will present insights into tau protein's post-translational modifications and their regulation, as well as the latest advancements in tau-targeted diagnostics and therapies [4][9]. Group 3: Key Topics of Discussion - The lecture will cover the structural characteristics of tau protein, its six isoforms, and biological functions [9][14]. - It will delve into the post-translational modifications of tau and their regulatory mechanisms [9][14]. - The discussion will also include the pathogenic mechanisms of tau-related neurodegenerative diseases, particularly Alzheimer's disease, and the progress and prospects of tau-targeted diagnostic and therapeutic strategies [9][14].