Cell：高分子量tau蛋白抑制海马体神经元活动，导致阿尔茨海默病的认知衰退

Core Insights - The article discusses the relationship between tau protein and cognitive decline in Alzheimer's disease (AD), highlighting that soluble tau protein, rather than tangles, is closely associated with the clinical progression of AD [2][3][5] - Recent research published in the journal Cell reveals that high-molecular-weight tau protein derived from Alzheimer's patients impairs the bursting activity of hippocampal neurons, indicating a cellular mechanism behind tau-dependent cognitive decline [3][5] Group 1: Research Findings - The study confirms that tau protein selectively weakens the complex bursting activity of CA1 neurons in the hippocampus, which is essential for learning and memory [5] - Impairment of bursting activity is linked to changes in hippocampal network activity, associated with theta rhythms and high-frequency ripple waves, along with a reduction in CaV2.3 calcium channel expression [5] - The research identifies soluble high-molecular-weight tau protein as a key subtype that inhibits bursting activity, suggesting it as a potential therapeutic target for Alzheimer's disease [5] Group 2: Upcoming Events - An online lecture titled "Tau's Structure, Modification, and Pathogenicity: Breakthroughs in Diagnosis and Treatment of Neurodegenerative Diseases" will be held on September 18, focusing on tau protein's dual role in neurons and neurodegenerative diseases [8]