西湖大学最新Cell子刊论文：利用孕妇肠道菌群预测早产风险

Core Insights - The article discusses the significant relationship between maternal gut microbiome during early pregnancy and the risk of preterm birth, highlighting the need for further understanding of this connection [2][3][4]. Group 1: Research Findings - A study involving a cohort of 5,313 pregnant women identified a direct association between early pregnancy gut microbiome characteristics and preterm birth risk [3][6]. - The gut bacterium Clostridium innocuum was identified as a novel biomarker for predicting preterm birth, with its presence correlating positively with preterm birth risk [3][7]. - The research established a preterm microbiome risk score (MRS) that effectively differentiates between women with shorter gestation periods and higher preterm birth risk [6][7]. Group 2: Mechanisms and Implications - Clostridium innocuum was found to degrade 17β-estradiol, a hormone linked to pregnancy outcomes, suggesting a mechanism by which it influences preterm birth risk [6][8]. - The study indicates that maternal polygenic risk for preterm birth is amplified by the presence of Clostridium innocuum, emphasizing the interaction between genetic susceptibility and microbiome composition [6][7].