世界首个AI设计的病毒诞生，能够感染并杀死耐药细菌，人类达成AI生成生命的里程碑！

Core Viewpoint - The article discusses a significant advancement in artificial intelligence (AI) where the first AI-designed virus (bacteriophage) has been created, capable of infecting and killing antibiotic-resistant bacteria, showcasing the potential of AI in developing biotechnological tools and therapies for bacterial infections [3][11]. Group 1: AI and Virus Design - The research published on September 17, 2025, demonstrates the ability of AI to design a complete viral genome, marking a major step towards AI-generated life [3][6]. - The AI models, Evo 1 and Evo 2, were trained on extensive genomic data, enabling them to predict and generate DNA sequences at a genome scale [7][11]. - The team used the bacteriophage ΦX174 as a template for designing the viral genome, which consists of 5,386 nucleotides and encodes 11 genes, showcasing the complexity of the design process [8][9]. Group 2: Research Findings - The research team evaluated thousands of AI-generated sequences, narrowing them down to 302 viable candidates, with 16 capable of self-replication and specifically infecting E. coli strains [11][12]. - Among the functional genomes, each contained 67-392 new mutations compared to their closest natural counterparts, indicating the potential for creating new species through AI [12]. - The AI-designed phages demonstrated the ability to infect and kill three different E. coli strains, outperforming the wild-type ΦX174 phage [11][12]. Group 3: Safety and Future Applications - Concerns about the potential misuse of AI models for harmful virus design are addressed, emphasizing that the training data excluded viruses affecting eukaryotes, including humans [14]. - The research team aims to utilize this method for safely generating AI-designed viruses to tackle various diseases and public health issues, particularly antibiotic resistance [15].