《柳叶刀》重磅披露：口服纤体新药功效史无前例，体重剧降15.1%，逾半受试者血糖理想达标！

Core Viewpoint - The article discusses the significant weight loss effects of oral semaglutide in overweight or obese patients without diabetes, highlighting the results of the OASIS 1 study and the PIONEER PLUS study, which demonstrate its efficacy and safety in weight management and blood sugar control [6][20]. Group 1: OASIS 1 Study Findings - The OASIS 1 study showed that daily oral administration of 50mg semaglutide led to an average weight loss of 15.1% after 68 weeks, with 85% of participants achieving clinically meaningful weight loss (≥5%) [6][9]. - The study included 667 adults with a BMI of ≥30kg/m² or ≥27kg/m² with weight-related complications, randomly assigned to either the semaglutide group or a placebo group [6][8]. - The treatment demonstrated a significant difference in weight loss compared to the placebo group, which only saw a 2.4% reduction (p<0.0001) [9][11]. Group 2: PIONEER PLUS Study Insights - The PIONEER PLUS study focused on the effects of high-dose oral semaglutide on blood sugar control in patients with type 2 diabetes and obesity, showing that higher doses (25mg or 50mg) resulted in better glycemic control and weight loss compared to the standard 14mg dose [20]. - Results indicated that the 50mg dose group achieved an average HbA1c reduction of 2.0%, with 63% of patients reaching the target HbA1c <7.0% [18][20]. - The study also reported that patients in the higher dose groups had a higher percentage of weight loss exceeding 5% or 10% compared to the standard dose group [18][20]. Group 3: Safety and Tolerability - The overall tolerability of semaglutide treatment was good, with 80% of patients reporting gastrointestinal adverse effects, mostly mild to moderate [13][15]. - The incidence of any adverse events was higher in the semaglutide group (91.9%) compared to the placebo group (85.6%), but serious adverse events were relatively low [15]. - Common adverse events included nausea (51.8% in the semaglutide group) and gastrointestinal disorders, but no fatal events were reported [15].