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中国科学院发表最新Nature论文
生物世界·2025-09-24 00:00

Core Viewpoint - The research conducted by the team led by Shen Qilong from the Shanghai Institute of Organic Chemistry decodes the redox behavior of copper in Ullmann-type coupling reactions, providing new insights into the catalytic mechanisms involved [2][3][5]. Group 1 - The study reveals the reaction process between well-defined Cu(I) complexes and electron-deficient aryl iodides, leading to the formation of separable Cu(III)-aryl complexes, which subsequently undergo reductive elimination to form C(sp²)−CF₃ bonds [4]. - The research demonstrates that the copper species undergo an oxidation-reduction cycle involving Cu(I)/Cu(III)/Cu(II)/Cu(III)/Cu(I), highlighting the complexity of copper's behavior in these reactions [4][5]. - The team successfully interrupted the catalytic cycle using temperature control and captured the reactivity of copper species through various spectroscopic methods, allowing for an in-depth mechanistic analysis [4][5].