Nature子刊：浙江大学顾臻团队发明“声控胶囊”，巧用共振原理，实现药物受控释放

Core Viewpoint - The article discusses the development of a biomimetic cilia-based array system inspired by cochlear hair cells, which utilizes acoustic resonance for sound frequency decoding and resonance-responsive drug release [3][4][7]. Group 1: Research Background - The research team, led by Professor Gu Zhen and Researcher Wang Jinqiang from Zhejiang University, published a paper in Nature Biomedical Engineering detailing their innovative approach to sound signal visualization and drug delivery [3][4]. - The human auditory system's ability to perceive sound through the resonance of the basilar membrane and hair cells serves as the foundation for this research [7][8]. Group 2: Technology Development - The team created a micro-scale artificial cilia array (40-200 micrometers) with varying length-to-diameter ratios (30-100) to detect and decode sound frequencies ranging from 100 to 6000 Hz, covering the primary range of human hearing [8]. - The artificial cilia array demonstrated the ability to decode sound signals from piano music and complex human voice signals [8]. Group 3: Drug Delivery Application - The artificial cilia array was tested in a liquid environment, showing that acoustic resonance could significantly enhance the release and diffusion of model drugs [8]. - In diabetes treatment, insulin and glucagon were loaded onto different cilia arrays, allowing for selective drug release triggered by specific acoustic frequencies, effectively regulating blood sugar levels [9]. Group 4: Future Prospects - The artificial cilia array has the potential to be optimized for a broader frequency range and could decode complex acoustic signals, facilitating personalized medical applications [10]. - This technology may enable the detection of various physiological sounds, such as breathing patterns and heartbeats, and could be used for disease monitoring and controlled drug release [10].