新研究揭示肥胖隐藏诱因：为何"少吃多动"效果有限？

Core Viewpoint - Obesity is recognized as one of the most severe global public health crises of the 21st century, with the number of overweight individuals having nearly tripled over the past fifty years, according to the World Health Organization [3] Group 1: Traditional Views and New Research - The traditional view of obesity as a simple energy imbalance has dominated prevention strategies for decades, but recent research by Professor Barbara E. Corkey indicates that the causes of obesity are far more complex [4][6] - Corkey's groundbreaking research highlights the role of metabolic disruptors, such as food additives and environmental endocrine disruptors, which may be altering the body's metabolic regulation mechanisms [4][6] Group 2: The Mystery of "Eat Less, Move More" - The long-held belief that "eat less, move more" is the key to combating obesity is being challenged, as many individuals find it difficult to lose weight despite strict dietary control and exercise [6] - Corkey's research identifies environmental "obesogens" that interfere with metabolic regulation, changing fat storage methods and appetite signaling, thus complicating weight loss efforts [6][8] Group 3: Sources of Obesogens - Obesogens are found in various aspects of modern life, including ultra-processed foods, industrial pollutants in drinking water, and chemicals in everyday products, which can enter the body through multiple pathways [8][9] - The presence of these chemicals can disrupt the body's energy regulation, leading to incorrect hunger signals and excessive fat accumulation, even in individuals maintaining a healthy diet and exercise routine [8][9] Group 4: A New Paradigm in Obesity Research - The field of obesity research is undergoing a fundamental shift, moving from a focus on individual behavior to a broader understanding of environmental health factors, as proposed by Corkey's obesogen theory [10][11] - This new paradigm emphasizes the need for a systematic research framework to identify potential obesogens, understand their molecular mechanisms, and develop practical exposure-blocking strategies [10][11] Group 5: Comprehensive Strategies for Obesity Prevention - The emergence of the obesogen theory calls for a dual approach to obesity prevention, combining personal health management with societal environmental changes [12] - A comprehensive prevention model that integrates micro-level behavior interventions with macro-level environmental governance is essential to effectively combat the obesity epidemic and improve public health [12]