Nature：“为什么瘦身总是如此艰难，坚持更不容易？原来肥胖还会形成‘记忆’！”

Core Viewpoint - The article discusses the phenomenon of "obesity memory," which explains why maintaining weight loss is challenging even after significant weight reduction. This memory is attributed to epigenetic changes in fat cells that persist long after weight loss, affecting gene expression and cellular function [6][7][10]. Group 1: Research Findings - Research indicates that fat cells retain a "memory" of obesity, which complicates weight maintenance post-weight loss [6]. - The study published in Nature reveals that epigenetic changes caused by obesity lead to lasting alterations in gene activity, even when individuals return to a healthy weight [8]. - The analysis of fat tissue from severely obese individuals shows that certain genes remain more active while others are less active compared to those who have never been obese, indicating a persistent obesity-related gene expression pattern [10]. Group 2: Implications for Weight Management - Experts suggest that individuals aiming to lose weight may require long-term support and management to prevent weight regain, emphasizing that the struggle is not solely the individual's fault [10]. - The research highlights the need for a deeper understanding of the molecular mechanisms behind weight regain, as current knowledge remains limited [12]. - The findings suggest that preventing obesity is the most effective strategy, and maintaining weight loss demands significant effort and determination from individuals [13].