《Science》：中年男性发胖几乎成定局！真正原因竟然与新陈代谢无关

Core Viewpoint - The article discusses the phenomenon of "middle-aged weight gain," highlighting the biological mechanisms behind fat accumulation in middle-aged individuals, particularly focusing on the role of newly identified stem cells in fat tissue development [6][8][17]. Group 1: Middle-Aged Weight Gain - Many individuals experience gradual weight gain between the ages of 30 and 60, with studies indicating an average annual weight increase of 0.5 to 1 kg for Americans aged 21 to 55, and 0.7 kg for women aged 40 to 60 [7][8]. - The article emphasizes that weight gain in middle age is not solely due to increased caloric intake or decreased physical activity, but rather a complex interplay of biological factors [7][9]. Group 2: Metabolism and Fat Accumulation - Contrary to popular belief, metabolism does not significantly decline until after the age of 60, with a stable metabolic rate observed from ages 20 to 60 [11]. - The study indicates that fat accumulation, particularly visceral fat, is more pronounced in middle-aged individuals, which poses health risks such as diabetes and heart disease [12][8]. Group 3: Role of Stem Cells in Fat Tissue - Research reveals that aging activates a new type of adipose precursor cell (APC) that contributes to the generation of new fat cells, particularly in the abdominal region [16][17]. - The presence of a newly identified cell subgroup, age-specific adipose precursor cells (CP-A), increases significantly in middle-aged individuals, suggesting a unique mechanism of fat cell generation that is age and gender-specific [17][18]. Group 4: Implications for Health - The findings provide insights into the mechanisms of age-related metabolic disorders and highlight the potential for developing targeted therapies to manage age-related obesity [17][18].