司美格鲁肽减重降糖这么猛，普通人减重使用会不会低血糖？

Core Viewpoint - Semaglutide, a GLP-1 receptor agonist, effectively lowers blood sugar levels and aids in weight loss, making it a comprehensive treatment option for type 2 diabetes patients [4][6]. Mechanism of Action - Semaglutide mimics the action of the natural GLP-1 hormone, promoting insulin secretion when blood sugar levels are high and suppressing glucagon secretion when levels are normal [4]. - It reduces appetite through three main mechanisms: central nervous system effects, gastrointestinal effects, and changes in food preferences [7][11][13]. Central Nervous System Effects - Semaglutide acts on the hypothalamus, a key area for appetite regulation, reducing hunger and food intake by activating GLP-1 receptors [7][9]. Gastrointestinal Effects - It slows gastric emptying, increasing feelings of fullness and reducing food intake, which also helps in controlling postprandial blood sugar levels [11]. Changes in Food Preferences - Clinical studies indicate that semaglutide reduces patients' preferences for high-fat, fried, or sweet foods, likely due to its influence on the brain's appetite regulation centers [13]. Weight Loss Data - In the PIONEER PLUS study, participants taking oral semaglutide lost an average of 9.2 kg (9.54%) and 7.0 kg (7.26%) with doses of 50 mg and 25 mg, respectively, over 68 weeks [15]. - The OASIS 1 study showed that participants with an average baseline weight of 105.4 kg lost an average of 18.34 kg (17.4%) with the 50 mg dose [15]. - The OASIS 4 study reported a 13.6% (14.4 kg) weight loss over 64 weeks, with potential for up to 16.6% (17.6 kg) if all participants completed the treatment [16].