GLP-1药物竟治愈20年顽固异食癖！ENDO大会揭秘"饥饿激素"新疗法

Core Insights - A groundbreaking case presented at ENDO 2025 demonstrated that a new GLP-1 receptor agonist successfully reversed a 20-year case of severe pica, attracting significant attention in the endocrinology community [4][6][9]. Group 1: Case Study Details - The case involved a 50-year-old female patient who had been consuming nearly 1 pound of corn starch daily for over 20 years, leading to severe iron deficiency anemia [11][13]. - After 5 months of treatment with the GLP-1 receptor agonist, the patient lost 34 pounds (approximately 15 kg) and completely lost her craving for corn starch [12][14]. Group 2: Treatment and Mechanism - The treatment regimen included the GLP-1 receptor agonist semaglutide, which was gradually increased to a maximum dose of 2.4 mg per week, alongside initial medications for anxiety and stomach issues [13][14]. - The findings suggest that GLP-1 receptor agonists may influence the brain's appetite control system, providing a potential new avenue for treating eating disorders like pica [15][16]. Group 3: Implications and Future Research - This case provides strong clinical evidence supporting the theory that GLP-1 receptor agonists can affect the human reward system pathways, opening new research directions for understanding eating disorders [15]. - Experts emphasize the need for larger clinical studies to confirm the efficacy and potential applications of GLP-1 receptor agonists in treating various eating disorders [16].