Nature子刊：浙江大学方向前/赵玥绮/唐睿康/刘昭明团队开发抗衰老的时空自适应纳米疗法

Core Insights - The article discusses a new research study that addresses the impaired cellular behavior during the healing process in the elderly, focusing on the role of pro-inflammatory macrophages and aging stem cells in tissue regeneration [2][6]. Group 1: Research Findings - A research team from Zhejiang University and affiliated hospitals developed a spatiotemporal-adaptive nanotherapeutic system that utilizes a glucose-modified mixed membrane delivery strategy to precisely regulate metabolic reprogramming [3][6]. - The system employs NAD+ loaded ZIF-8 nanoparticles (NZM) to target pro-inflammatory macrophages during the inflammatory phase, triggering the release of NAD+ and inducing an anti-inflammatory transition [6]. - In the repair phase, the system restores NAD+ levels in aging stem cells, promoting tissue regeneration [6]. Group 2: Implications and Applications - The study demonstrates that the NAD+ can reprogram dysfunctional cells, effectively reshaping the multicellular regenerative microenvironment [6]. - The proposed strategy has shown to restore bone regeneration capabilities in osteoporotic mice and accelerate skin wound healing [6][7]. - This research connects cellular metabolism, nanomedicine, and regenerative therapy, offering a promising and translatable new strategy for precise clinical interventions [7].