低剂量司美格鲁肽：既能显著减重，又能减少副作用

Core Viewpoint - The article discusses the effectiveness of personalized dosing of semaglutide in weight management, emphasizing its role in preventing weight regain when combined with lifestyle guidance and support [4][6]. Group 1: Research Findings - A recent study presented at the European Obesity Congress (ECO) highlights the advantages of using personalized doses of semaglutide in weight loss programs [4]. - The study involved 2,246 individuals in Denmark, primarily women with an average age of 49 and a BMI of 33.2, participating in a weight management program that included dietary advice, exercise, and psychological support [9]. - The average weight loss reported at week 64 was 14.8% (approximately 14.8 kg), and at week 76, it was 14.9% (approximately 14.9 kg) [12]. Group 2: Treatment Protocol - The standard dosing protocol for semaglutide is tailored to minimize side effects, starting with a lower initial dose and gradually increasing it based on individual progress [11]. - The average maximum dose of semaglutide used in the study was 0.77 mg, which is about one-third of the standard treatment protocol [12]. - At week 64, all patients reported a weight loss of over 5%, with 85.3% of patients losing more than 10% of their baseline weight [13]. Group 3: Side Effects and Management - While semaglutide is effective for weight loss, it can cause side effects such as diarrhea, nausea, and headaches [6]. - Recent findings suggest that patients receiving nutritional and exercise guidance alongside medication are less likely to experience weight regain after stopping the drug [6].