浙大校友一作Nature论文：饮食中的这种氨基酸，能够促进肠道修复和再生

Core Viewpoint - The research highlights the role of dietary cysteine in enhancing intestinal stem cell function and promoting tissue repair after gut damage, particularly in patients undergoing cancer treatments like chemotherapy and radiotherapy [4][10]. Group 1: Research Findings - The study published in Nature demonstrates that dietary cysteine stimulates CD8+ T cells to secrete IL-22, which is crucial for intestinal stem cell proliferation and tissue repair [4][10]. - Cysteine enhances the biosynthesis of coenzyme A (CoA) in intestinal epithelial cells, leading to the unexpected secretion of IL-22 by CD8αβ+ T cells, thereby improving gut repair capabilities [7][10]. - The research team confirmed that CoA supplementation can replicate the effects of cysteine, while the absence of specific cysteine transport proteins blocks these effects [8]. Group 2: Clinical Implications - The findings suggest that a diet rich in cysteine could serve as a potential adjunct therapy for cancer patients experiencing gut damage due to treatments, significantly improving recovery rates from intestinal injuries [10][11]. - The study opens avenues for developing nutritional strategies and possible supplement formulations aimed at enhancing gut health and repair during cancer treatments and inflammatory bowel diseases [10][11]. Group 3: Broader Impact - Initial research indicates that cysteine may also promote regeneration in other stem cell populations and organs, suggesting a wider impact on various tissue types [11]. - The study emphasizes the need for human clinical trials to validate the translational potential of these findings, which could revolutionize approaches in oncology, gastroenterology, and regenerative medicine [11].