天津大学最新Cell子刊论文：茶多酚增强的蛋白质水凝胶，促进牙周骨再生

Core Viewpoint - Guided Bone Regeneration (GBR) is a crucial technique in dental and maxillofacial surgery for repairing bone defects caused by periodontal disease, trauma, or implant surgery, utilizing barrier membranes to promote bone regeneration while preventing faster migrating connective tissue from entering the defect area [2]. Group 1: GBR Membrane Development - Numerous GBR membranes have been developed, with collagen-based membranes like Bio-Gide favored for their biocompatibility and biodegradability, yet they face challenges such as rapid degradation and insufficient mechanical properties [2]. - The need for natural polymer-based materials with superior mechanical properties for GBR membranes is emphasized due to issues like membrane displacement and loss of bone grafts during the healing process [2]. Group 2: Research Findings - A study published in Cell Biomaterials by researchers from Tianjin University and Shandong University developed strong and tough natural protein hydrogels as GBR membranes regulated by tea polyphenols [3][4]. - The tea polyphenol-treated hydrogels exhibited excellent mechanical properties, including a tensile strength of 2.64 ± 0.20 MPa, a Young's modulus of 60.37 ± 2.71 MPa, and toughness of 1.83 ± 0.13 MJ/m³, surpassing most pure natural protein-based hydrogels [6]. - The asymmetric porous natural protein-based hydrogels serve as a physical barrier to prevent soft tissue infiltration while providing ample space for new bone growth, demonstrating significant effectiveness in promoting periodontal bone regeneration over a 12-week in vivo study [6][8].