Cell Stem Cell：刘光慧团队等首次证实，维生素C可延缓灵长类卵巢衰老

Core Viewpoint - The research indicates that oral administration of clinical safe doses of Vitamin C can significantly delay ovarian aging in primates, revealing its protective mechanism through the activation of the NRF2 signaling pathway [2][4][5]. Group 1: Research Background - Ovarian aging plays a critical role in women's reproductive health, impacting treatment strategies and quality of life [3]. - Previous studies by Liu Guanghui's team have established that Vitamin C can delay cellular aging and has been linked to a significant decline in antioxidant capacity during ovarian aging in primates [3]. Group 2: Key Findings - A 3.3-year intervention study on middle-aged crab-eating macaques demonstrated that oral Vitamin C can reduce key aging biomarkers, including oxidative stress and follicle depletion [4]. - The study constructed a primate ovarian single-cell transcriptome aging clock, showing that Vitamin C can make oocyte biological age younger by an average of 1.35 years and somatic cell biological age younger by 5.66 years, particularly in granulosa, endothelial, and stromal cells [4]. - Vitamin C effectively reverses aging and inflammation-related phenotypes in endothelial cells, making their biological age nearly 7 years younger [4]. Group 3: Mechanism of Action - The effect of Vitamin C in delaying ovarian aging is partially mediated through the NRF2 pathway, which plays multiple protective roles in human ovarian cells, including delaying aging, inhibiting inflammation, maintaining chromatin stability, and enhancing mitochondrial function [5]. Group 4: Implications - This research validates the concept of using a single compound to delay ovarian aging in primate models and highlights the potential of Vitamin C in developing interventions for human ovarian aging [8].