Nature重磅：鲸鱼长寿且不患癌症，关键在于这个DNA修复蛋白，或可帮助人类延长寿命

Core Insights - The article discusses the unique longevity and cancer resistance of the bowhead whale, which can live over 200 years, and highlights the role of a specific protein, Cold-inducible RNA-binding Protein (CIRBP), in DNA repair and genomic stability [3][6][11]. Group 1: Bowhead Whale Longevity - The bowhead whale has a lifespan exceeding 200 years, which is significantly longer than that of other mammals, such as mice, which live only 2-3 years [2]. - Despite its large size (over 80 tons) and the expectation of high cancer rates due to DNA mutations, the bowhead whale exhibits low cancer incidence, suggesting a unique genetic mechanism for cancer prevention [2][11]. Group 2: Research Findings - A study published in Nature identified CIRBP as a key protein activated in cold environments that aids in repairing DNA double-strand breaks, contributing to the bowhead whale's longevity and low cancer risk [3][6]. - The research demonstrated that expressing CIRBP in human cells enhances DNA repair capabilities, and in fruit flies, it extends lifespan and increases resistance to DNA-damaging radiation [9][11]. Group 3: Implications for Human Health - The findings suggest that enhancing DNA repair mechanisms could provide significant opportunities for extending human lifespan and improving health [4][11]. - The study indicates that bowhead whales maintain genomic integrity not by relying on additional anti-cancer genes but through superior DNA repair processes [11].