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Core Viewpoint - The article emphasizes the urgent need for weight management due to the global obesity crisis, which is linked to various metabolic diseases and health issues. It advocates for a dual approach to weight management: self-discipline through lifestyle changes and external interventions such as medication or surgery [6][10]. Summary by Sections Obesity as a Public Health Crisis - The National Health Commission has issued a warning about the critical state of public health due to obesity, which is a major contributor to diseases like type 2 diabetes and cardiovascular issues [6]. Weight Management Approaches - Effective weight management requires both self-discipline (through exercise, diet, and sleep) and external aids (such as medications and surgical options) [6]. GLP-1 Receptor Agonists - Medications like Semaglutide and Liraglutide, which are GLP-1 receptor agonists, have been approved for weight loss. These drugs mimic the natural peptide GLP-1 in the body, aiding in appetite control and energy balance [7]. Discovery of BRINP2-Related Peptide (BRP) - A new peptide, BRP, has been identified by a Stanford University team using AI tools. This peptide shows significant potential in reducing food intake and improving blood sugar levels, comparable to GLP-1 receptor agonists, without causing anxiety or behavioral changes [8][14]. Mechanism of Action - BRP operates independently from known appetite-related peptides and activates specific neuronal pathways in the hypothalamus to regulate appetite. It enhances fat oxidation and reduces overall food intake without adverse effects [14][16]. Experimental Results - In mouse studies, BRP significantly reduced food intake and body weight, improving glucose tolerance and insulin sensitivity. The effects were similar to those of Liraglutide, indicating its potential as a weight loss treatment [14][16]. Future Directions - The discovery of BRP opens new avenues for obesity treatment, although further research is needed to understand its mechanisms and long-term safety before clinical application [18].