Nature头条：每天走上几千步，推迟阿尔茨海默病数年

Core Insights - A recent study published in Nature Medicine indicates that walking a few thousand steps daily can slow the progression of Alzheimer's disease [4][5] - The research tracked 296 older adults over 14 years, revealing that walking more than 5,000 steps daily may reduce tau protein accumulation and cognitive decline in preclinical Alzheimer's disease [7][8] Group 1: Research Findings - The study involved participants aged 50-90 who showed no cognitive impairment at the start, with regular cognitive tests and brain scans conducted [7] - It was found that walking 3,000-7,500 steps daily benefits participants with higher baseline levels of beta-amyloid protein, slowing cognitive decline by 3 years for those walking 3,000-5,000 steps and by 7 years for those walking 5,000-7,500 steps [8][10] - For participants with lower beta-amyloid levels, the number of steps taken did not significantly impact cognitive ability [8] Group 2: Implications of Findings - The study highlights that increased physical activity, particularly walking, is associated with a reduction in tau protein accumulation, which is more closely linked to cognitive decline than beta-amyloid levels [10] - The research suggests that even modest amounts of daily walking can help mitigate the pathological changes associated with preclinical Alzheimer's disease [10] - The first author emphasizes that while the common goal of 10,000 steps may be challenging for many older adults, even a small amount of exercise appears beneficial [10]