疾病恢复期不想吃肉？华人学者Cell论文证实，这是身体通过肠道-大脑信号在自救

Core Viewpoint - The article discusses a recent study published in the journal Cell, revealing that during recovery from catabolic states, the body actively limits protein intake as a protective mechanism against potential harm, challenging traditional views on dietary needs post-illness [3][4][8]. Group 1: Research Findings - The study found that mice recovering from catabolic damage voluntarily restricted protein intake, even at the cost of overall caloric intake [4][10]. - Three specific amino acids—glutamine (Q), lysine (K), and threonine (T)—were identified as necessary and sufficient for the aversion to protein during recovery [4][12]. - The aversion to protein is driven by ammonia production in the gut, which is sensed by enterochromaffin cells through a TRPA1-dependent mechanism, leading to serotonin release that signals the brain to induce anorexia [4][14]. Group 2: Implications for Clinical Nutrition - The findings suggest that the traditional recommendation for high protein intake in recovering patients may be counterproductive and potentially harmful [8][16]. - It is recommended that protein intake should be personalized based on the patient's recovery stage and health status, particularly for those with impaired ammonia detoxification capabilities [16]. - The study emphasizes the importance of understanding the biological mechanisms behind appetite regulation, which could lead to more scientifically grounded rehabilitation nutrition strategies [16].