Cell子刊：华人学者证实，母亲糖尿病，儿子易患心血管疾病，女儿则不受影响

Core Insights - The rising incidence of cardiovascular diseases (CVD) among young people necessitates the identification of high-risk groups for targeted preventive measures [2][4] - Maternal diabetes is linked to an increased risk of early-onset cardiovascular diseases in male offspring, while female offspring are not affected [11][12] Group 1: Research Findings - A study published by a team from Karolinska Institute confirmed that sons of mothers with type 1 diabetes are at higher risk for early endothelial dysfunction and related cardiovascular diseases, independent of metabolic disorders [2][6][11] - The research utilized a mouse model to demonstrate that maternal hyperglycemia specifically leads to early endothelial dysfunction in male offspring, with oxidative stress and arginase-1 signaling pathways identified as potential mechanisms [6][11] - Epidemiological studies in Denmark and Sweden corroborated these findings, showing that sons of mothers with type 1 diabetes have an increased risk of early cardiovascular diseases associated with endothelial dysfunction [6][8][11] Group 2: Implications - The study highlights a previously underappreciated risk group for early cardiovascular disease, emphasizing the impact of maternal health on offspring cardiovascular health [12] - The findings suggest a need for future preventive strategies targeting this specific demographic, particularly focusing on the health of mothers with diabetes [11][12]