一文读懂！司美格鲁肽和替尔泊肽使用前体检指南（建议转发+收藏）

Core Viewpoint - The article discusses the increasing popularity and sales of Semaglutide in the Chinese market among obesity patients, highlighting the rapid development of domestic generic versions of the drug. Semaglutide is a novel weight loss and blood sugar regulation medication that mimics the natural hormone GLP-1, but it also has contraindications and side effects that require health assessments before use [4]. Group 1: Health Assessments Before Using Semaglutide - Patients with a family history of thyroid disease or a history of pancreatitis are generally advised against using Semaglutide. Thyroid function tests, including thyroid ultrasound, are recommended to assess the risk of thyroid C-cell tumors [4]. - Individuals with a history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2) should inform their healthcare provider, as these conditions may contraindicate the use of Semaglutide [5]. - Continuous monitoring for acute pancreatitis is essential, including abdominal ultrasounds or CT scans and blood lipid tests to assess triglyceride levels, as high triglycerides are a significant risk factor for pancreatitis [7]. Group 2: Additional Health Checks - Kidney function tests are necessary before starting Semaglutide treatment, as the drug is primarily excreted through the kidneys. Regular monitoring of kidney function is also required during treatment [7]. - Cardiac function assessments are crucial before initiating Semaglutide therapy to ensure patient suitability and monitor potential cardiovascular risks. This may include ECGs, biochemical blood tests, echocardiograms, and Holter monitoring if necessary [8]. Group 3: Overview of GLP-1 Drugs - GLP-1 (Glucagon-Like Peptide-1) is a hormone produced by intestinal L-cells and is classified as an incretin. GLP-1 receptor agonists are a new class of hypoglycemic drugs that enhance insulin secretion in a glucose-dependent manner, suppress glucagon secretion, and delay gastric emptying, thereby reducing food intake and achieving blood sugar reduction and weight loss [19].