广州中医药大学发表最新Cell子刊论文

Core Viewpoint - The study published by Professor Wu Baojian's team from Guangzhou University of Chinese Medicine in Cell Metabolism highlights the role of the intestinal clock in regulating the sleep-wake cycle through maintaining glutamine homeostasis, suggesting potential new targets for enhancing sleep rhythms and treating sleep disorders [2][7]. Summary by Sections Research Findings - The integrity of the intestinal epithelial cells (IEC) is essential for maintaining the circadian sleep-wake cycle [4]. - BMAL1 in the intestinal epithelial cells drives the circadian expression of SLC6A19, promoting glutamine absorption during active periods, which enhances the activity of glutamatergic neurons in the hypothalamus, thereby increasing wakefulness and reducing sleep [4][5]. - A lack of REV-ERBα in intestinal epithelial cells leads to elevated glutamine levels during rest phases, which is causally linked to sleep abnormalities characterized by reduced sleep [4][5]. Implications - The intestinal clock regulates glutamine homeostasis temporally, shaping the circadian sleep-wake cycle, and may serve as a potential target for enhancing sleep rhythms and treating sleep disorders [7].