STTT：黄荷凤院士团队发现多囊卵巢综合征治疗新靶点

Core Viewpoint - The study identifies pyruvate kinase M2 (PKM2) as a transcriptional regulator contributing to polycystic ovary syndrome (PCOS), highlighting its potential as a therapeutic target [4][7]. Group 1: Research Findings - The research team discovered that elevated lactylation levels of histone H3 at lysine 9/18 (H3K9/K18) are associated with PKM2 and genomic binding, altering the three-dimensional structure of the genome [4]. - In mice, ectopic expression of Pkm2 in follicular granulosa cells consistently exhibited PCOS-like characteristics, such as disrupted estrous cycles and hyperandrogenism [5]. - Pharmacological inhibition of PKM2 aggregation in the nucleus alleviated PCOS-like symptoms in mice and restored the transcriptome to wild-type levels [5]. Group 2: Implications - The study emphasizes the significant role of PKM2-mediated histone lactylation in regulating three-dimensional chromatin structure, suggesting its potential as a therapeutic target for PCOS [7].