医学博士：希望更多65岁以上老年人使用司美格鲁肽！每减一斤，每个关节减轻两斤重量

Core Viewpoint - The article emphasizes the benefits of GLP-1 medications, particularly for the elderly, highlighting that weight loss can significantly improve mobility, balance, and overall health, potentially allowing older adults to live more independently [2][6]. Group 1: Benefits of GLP-1 Medications for the Elderly - A significant portion of the elderly population is not utilizing GLP-1 medications, with only 9% of those aged 65 and older reporting usage compared to 19% in the 50-64 age group [4]. - Weight loss from GLP-1 medications can enhance mobility and reduce the need for assistive devices like wheelchairs or canes, as evidenced by patients who have experienced improved conditions post-weight loss [6][7]. - The reduction in weight can alleviate joint stress, with each pound lost equating to a reduction of 2 to 4 pounds of pressure on the joints, thus improving flexibility and reducing pain [6]. Group 2: Medical Considerations and Treatment Approaches - Physicians recommend a comprehensive approach for elderly patients, including consultations with nutritionists and physical rehabilitation to ensure safe engagement in physical activities [5]. - Dosage adjustments for GLP-1 medications may be necessary for elderly patients who are on multiple medications, ensuring safety and efficacy [5]. Group 3: Mechanism of Action of GLP-1 Medications - GLP-1 medications, such as semaglutide, mimic the hormone GLP-1, which helps lower blood sugar and promotes a feeling of fullness, thus aiding in weight management [9][11]. - These medications not only suppress appetite but also alter the body's metabolic response to food intake, indicating that obesity is a complex metabolic disease rather than merely a behavioral issue [11].