Nature Aging：新型CAR-T细胞疗法，逆转并预防衰老相关肠道问题

Core Insights - The article discusses the development of a CAR-T cell therapy targeting uPAR, which has shown potential in reversing and preventing aging-related defects in intestinal regeneration and health [2][3][8]. Group 1: Research Background - Intestinal stem cells (ISCs) drive the rapid regeneration of intestinal epithelial cells, but aging significantly reduces their regenerative capacity, leading to decreased intestinal function and increased permeability [6]. - There is a pressing need to develop strategies that can restore ISC function, especially given the high incidence of intestinal diseases in the elderly [6]. Group 2: uPAR and Aging - Previous studies have linked the expression of uPAR to aging and various conditions such as liver fibrosis and lung injury, but its role in intestinal biology and regeneration has not been thoroughly explored [7]. - The latest research indicates that uPAR-positive cells accumulate in aging intestines, adversely affecting ISC function [8]. Group 3: CAR-T Cell Therapy Findings - The study demonstrated that CAR-T cells targeting uPAR improved intestinal barrier function, regenerative capacity, inflammation, mucosal immunity, and gut microbiome composition in aged mice [8]. - These findings provide conceptual validation for the potential of immune-based targeted cell therapies to promote tissue regeneration in aging individuals [8].