《自然》：身体自带“记忆”机制！肥胖导致的脂肪表观变化难以完全恢复

Core Viewpoint - The article discusses the phenomenon of "fat memory," highlighting that the body retains cellular changes from obesity even after significant weight loss, making it easier to regain weight [8][12][18]. Group 1: Research Findings - A study from the Swiss Federal Institute of Technology analyzed fat tissue from successful weight loss participants, revealing that transcriptional changes induced by obesity persist even two years post-weight loss [9][12]. - In mouse experiments, previously obese mice showed a heightened ability to absorb sugars and fats, leading to faster weight regain when reintroduced to a high-fat diet compared to never-obese mice [8][19]. - The study found that 57-62% of downregulated and 68-75% of upregulated differentially expressed genes (DEGs) post-weight loss could be explained by epigenetic mechanisms [18]. Group 2: Implications of "Fat Memory" - The presence of "fat memory" suggests that individuals who have been obese may face increased difficulty in maintaining weight loss, as their bodies are predisposed to regain weight more rapidly [20][21]. - The research indicates that the duration of obesity may correlate with the severity of "fat memory," with longer periods of obesity leading to more pronounced cellular changes that resist normalization post-weight loss [16][18].