这篇重磅Cell论文发表一年后，作者主动申请撤稿

Core Viewpoint - The article discusses the significance of long non-coding RNAs (lncRNAs) in human genetics, emphasizing their essential roles in cancer and development, despite being previously considered non-functional or "junk" DNA [2][4]. Group 1: Research Development - A new CRISPR-Cas13 based screening technology was developed to target RNA at a transcriptome scale, allowing for the identification of 778 essential lncRNAs across five human cell types [4]. - This research indicates that many lncRNAs play crucial roles in human biology, challenging the notion that they are merely non-functional sequences [4]. Group 2: Research Withdrawal - The authors of the study announced the retraction of their paper due to the discovery of unfiltered off-target sequences in their CRISPR library, which could have led to inaccurate results [6][8]. - Following the identification of potential off-targets, the authors conducted a re-analysis of their data and updated their experiments, which resulted in changes to the identified essential lncRNAs [9].