BMJ子刊：每天几杯咖啡，延长端粒长度，减缓生物学衰老5年

Core Viewpoint - Coffee consumption is associated with potential health benefits, particularly in reducing biological aging in individuals with severe mental disorders, with a recommended intake of up to 4 cups per day showing the most significant positive effects [2][11]. Group 1: Research Findings - A study published in BMJ Mental Health found that daily consumption of up to 4 cups of coffee is linked to longer telomere length, which corresponds to a biological age reduction of approximately 5 years [2][11]. - The research involved 436 patients with severe mental disorders, including schizophrenia and mood disorders, and measured their telomere lengths in relation to their coffee intake [7][11]. - The relationship between coffee consumption and telomere length displayed a "reverse J-shaped" curve, indicating that moderate consumption is beneficial, while excessive intake (5 cups or more) does not provide additional benefits and may even be harmful [8][9]. Group 2: Mechanisms of Action - Coffee contains various bioactive compounds that exhibit strong antioxidant and anti-inflammatory properties, which may help protect telomeres from oxidative stress and chronic inflammation, common in individuals with severe mental disorders [13]. - Key components in coffee, such as caffeine, may activate telomerase, an enzyme that can repair and extend telomeres, thus contributing to the maintenance of telomere length [13]. Group 3: Implications for Public Health - The study emphasizes the importance of moderation in dietary habits, suggesting that even beneficial foods can have adverse effects when consumed excessively [14]. - It encourages further exploration into how diet and lifestyle factors influence biological aging processes in populations with mental health issues [15].