南京医科大学发表最新Cell Stem Cell论文

Core Insights - The article discusses a significant research study on the nucleus basalis of Meynert (nbM), highlighting its role in regulating cortical functions, learning, and memory, and its association with neurodegenerative diseases and developmental disorders [2][3]. Group 1: Research Findings - The research team successfully generated human nucleus basalis organoids (hnbMO) from human pluripotent stem cells (hPSC), which contain functional cholinergic projection neurons [5]. - The study established long-distance cholinergic projection pathways from nbM to the cerebral cortex by co-culturing hnbMO with fetal brain tissue and transplanting it into immunodeficient mice [5]. - The nbM-cortical organoid assembloids demonstrated human-specific cholinergic projection systems, confirming the functional connectivity between hnbMO and human cortical organoids (hCO) [5][6]. Group 2: Application and Implications - The organoid assembloids revealed projection defects in organoids derived from patients with Down syndrome, indicating their potential application in studying nbM-related neural circuits and neurological disorders [6]. - The research underscores the importance of the nbM-cortical cholinergic pathway in understanding the mechanisms underlying various neurological conditions [3][6].