全球与中国硝酸甘油原料药市场现状及未来发展趋势

Core Viewpoint - Nitroglycerin, a key active pharmaceutical ingredient (API) for treating angina, has a stable clinical application with moderate growth in demand driven by increasing cardiovascular disease rates. The market is characterized by stringent safety regulations and a focus on automation and green production technologies [3][4][6]. Industry Status Analysis - The nitroglycerin API market is stable but not rapidly growing, primarily driven by rigid demand from anti-angina formulations. The market faces challenges such as high safety production costs, environmental pressures, and limited market size [3][4]. - Regulatory scrutiny has increased compliance costs, leading to the exit of non-compliant capacities from the market, resulting in tighter supply and slight price increases [3][4]. - Recent advancements in production technology, including automation and continuous reaction systems, have improved safety and efficiency, helping domestic companies maintain competitiveness in international markets [3][4]. Development Trends - The demand for nitroglycerin APIs is expected to grow moderately, particularly in emerging markets like Asia, Latin America, and the Middle East, where procurement from primary healthcare institutions is increasing [6][7]. - In developed regions, the market is characterized by low growth and stable demand due to the fixed usage of nitroglycerin as a classic generic drug, with a shift towards supply chain security and drug quality consistency [6][7]. - The global nitroglycerin API market is projected to reach USD 5.973 billion in 2024 and USD 8.731 billion by 2031, with a compound annual growth rate (CAGR) of 5.51% from 2025 to 2031 [7][11]. Supply Chain Analysis - The upstream supply of nitroglycerin APIs relies on glycerin, nitric acid, sulfuric acid, and anhydrous ethanol, with varying sensitivities to market conditions and regulatory requirements [22][23]. - Compliance and logistics are critical constraints, as the production of nitroglycerin involves hazardous chemicals subject to strict regulations, impacting availability and costs [22][23]. Key Manufacturers - Major global manufacturers of nitroglycerin APIs include Novasep, Copperhead Chemical, Dipharma, Bharat Pharma, Shandong Xinyi Pharmaceutical, Beijing Yimin Pharmaceutical, and Lesheng Pharmaceutical, with the top five companies holding a 77.16% market share in 2024 [11].