使用司美格鲁肽减重时，吃够蛋白质有多重要！

Core Viewpoint - The article emphasizes the importance of adequate protein intake and a balanced diet for individuals using semaglutide, a GLP-1 receptor agonist, for weight loss and diabetes management [2][4][5]. Group 1: Importance of Protein and Diet - Adequate protein intake is crucial when using semaglutide to maintain muscle mass during weight loss [2]. - A balanced diet that includes high fiber foods, such as vegetables and whole grains, is recommended to reduce side effects like constipation and to enhance satiety [2][4]. - The use of multivitamins may help address nutritional deficiencies that arise from reduced food intake during weight loss [4]. Group 2: Mechanism of GLP-1 Drugs - GLP-1 receptor agonists, like semaglutide, mimic the action of the natural hormone GLP-1, which plays a significant role in blood sugar regulation [6]. - These drugs promote insulin secretion from pancreatic beta cells in a glucose-dependent manner, helping to lower postprandial blood sugar levels [6]. - They inhibit glucagon secretion from alpha cells, which typically raises blood sugar levels, thus contributing to lower blood sugar [6]. - GLP-1 receptor agonists delay gastric emptying, reducing the rate at which food enters the small intestine, which aids in controlling post-meal blood sugar spikes [7]. - They also act on the brain's appetite regulation centers to suppress appetite, assisting in weight management [8]. - Long-term use may improve or protect pancreatic beta cell function, which is particularly important for type 2 diabetes patients [9]. Group 3: Impact on Metabolism - A study indicated that semaglutide not only increases satiety but also directly affects metabolism, leading to increased energy expenditure [10]. - The basal metabolic rate (BMR), which accounts for approximately 70% of daily energy expenditure, may be enhanced in individuals using GLP-1 analogs, making it easier to lose weight [11]. - Increased metabolic activity in users of GLP-1 drugs suggests that these medications play a significant role in weight loss by promoting higher energy consumption [11][13].