南京农业大学发表最新Nature子刊论文

Core Viewpoint - The article discusses a recent study on the zoonotic pathogen Streptococcus equi subsp. zooepidemicus, which is linked to a meningitis outbreak in the pig industry in North America and Europe, highlighting its implications for both animal and human health [2][4]. Group 1: Research Findings - The study published by a team from Nanjing Agricultural University reveals that the pathogen utilizes a continuously transcribed phosphotransferase system (PTS man) to adapt metabolically in low-glucose environments, allowing it to proliferate in cerebrospinal fluid (CSF) [3][8]. - The research indicates that during systemic infection in mice, only about 1 to 10 clones of the pathogen invade the meninges, where they can multiply approximately 10 million times [7]. - The PTS man system is essential for glucose uptake in the pathogen, enabling it to limit the activation of stringent response and thus facilitating its replication in CSF [7][8]. Group 2: Implications for Treatment - The findings provide a new theoretical basis for the prevention and treatment of meningitis caused by Streptococcus equi subsp. zooepidemicus, suggesting potential targets for vaccine and drug development [4].