年末想大吃大喝，可以暂停使用司美格鲁肽等减重药物吗？

Core Viewpoint - The article discusses the use of GLP-1 receptor agonists, particularly semaglutide, for weight management and the implications of pausing medication, emphasizing the importance of gradual dosage reduction to mitigate hunger rebound effects [4][12][14]. Group 1: Medication Effects and Timeline - After subcutaneous injection, semaglutide is absorbed into the bloodstream within 1-2 hours [8] - Peak concentration in the blood occurs within 24-48 hours, where the drug actively binds to GLP-1 receptors [9] - Noticeable effects, such as reduced appetite and improved blood sugar regulation, may begin within 1-2 weeks [10] - Steady-state levels are achieved after 4-5 weeks of weekly injections, leading to more pronounced appetite suppression and accelerated weight loss [11] Group 2: Discontinuation Strategies - It is recommended to start with the lowest dose and gradually increase to minimize side effects [12] - Gradual dose reduction is preferred over abrupt cessation to avoid increased hunger [14] - Monitoring appetite and weight changes is crucial for those planning to stop medication, with a focus on maintaining healthy eating and exercise habits [14] Group 3: Post-Discontinuation Outcomes - A 2021 clinical trial showed that participants lost an average of 10.6% of their weight during 20 weeks of semaglutide treatment, but those switched to a placebo regained an average of 6.9% of their weight [15] - An observational study indicated that 18% of patients regained their lost weight after one year off the medication, while 26% regained more than 25% of their lost weight [15] Group 4: Importance of Continued Medication - The STEP 5 trial demonstrated that continuous use of semaglutide for 2 years resulted in a 15.2% weight loss compared to placebo [18] - In the SELECT trial, patients maintained an average weight loss of about 10% over 4 years, highlighting the chronic nature of obesity and the need for long-term management [18] Group 5: Obesity as a Chronic Disease - Recent studies confirm obesity as a chronic disease, with 76.8% of patients and 94.6% of doctors agreeing on its classification [19] - Obesity is linked to various health issues, including type 2 diabetes and cardiovascular diseases, necessitating its inclusion in chronic disease management [19] Group 6: Weight Loss and Health Improvement - Weight loss of 5% can improve hypertension and blood sugar levels, while a 10-15% reduction significantly lowers risks of cardiovascular diseases and diabetes [21] - Greater weight loss (over 15%) can effectively alleviate type 2 diabetes symptoms and improve overall health outcomes [21]