使用司美格鲁肽减重时，如何影响身体成分变化？

Core Viewpoint - GLP-1 receptor agonists, such as semaglutide, not only alter external appearance but also significantly impact body composition, which is crucial for understanding overall health effects beyond standard weight loss metrics [4][5][6] Group 1: Impact on Body Composition - The study analyzed 241 patients using semaglutide, comparing abdominal CT scans before and after five years of treatment, revealing significant changes in body composition [8] - In the weight loss group, reductions were observed in visceral fat area, subcutaneous fat area, muscle area, and liver volume, with an increase in liver density, indicating positive changes for cardiovascular metabolic health [8] - Conversely, in the weight gain group, increases in visceral fat area, subcutaneous fat area, and intermuscular fat area were noted, along with a decrease in muscle density, highlighting the importance of body composition metrics [8][9] Group 2: Importance of Advanced Metrics - Traditional clinical assessments like weight, waist circumference, and BMI fail to capture critical tissue-specific changes that can be evaluated through CT scans, which are essential for understanding the full impact of GLP-1 agonist treatments [9]