Cell Metabolism：这种大蒜瓣中的天然化合物，可延长寿命，改善健康

Core Viewpoint - The article discusses the potential of enhancing hydrogen sulfide (H₂S) generation through natural compounds, specifically diallyl sulfides (DAS), to promote healthspan and lifespan in mammals, particularly male mice [5][8]. Group 1: H₂S Generation Mechanisms - H₂S is generated through both non-enzymatic and enzymatic mechanisms, with the non-enzymatic pathway involving sulfur donors such as cysteine and homocysteine [1]. - Natural sulfur compounds, particularly those found in garlic, are highlighted for their ability to release H₂S in the body, making them significant for research on H₂S's physiological functions [1]. Group 2: Research Findings - A study published in Cell Metabolism indicates that enhanced non-enzymatic H₂S generation can extend lifespan and healthspan in male mice [3]. - The research shows that DAS not only prolongs the lifespan of wild-type male mice but also improves key health indicators throughout their life, including glucose regulation, motor function, and cognitive abilities [6]. - Observations at the histological and molecular levels revealed reduced liver lipid droplet volume and decreased activity in mTOR and immune-related pathways, alongside increased levels of protein persulfidation [6]. Group 3: Implications for Human Health - In human studies, higher levels of protein persulfidation in individuals with multiple pathological conditions are associated with enhanced muscle strength and reduced triglyceride levels, supporting the physiological relevance of this modification [6].