《自然·代谢》最新重磅：还能随心吃不易胖？科学家锁定关键神经元机制，让你“怎么吃都不胖”！

Core Viewpoint - The article discusses a recent study that reveals the role of a metabolite called Lac-Phe, produced during exercise, in suppressing appetite and aiding weight control, thereby enhancing understanding of the relationship between exercise and appetite regulation [6][10][12]. Group 1: Research Findings - A study published in Nature by researchers from Stanford University and Baylor College of Medicine identified Lac-Phe, a small molecule formed during exercise, which significantly reduces food intake and helps control weight [7][10]. - High doses of Lac-Phe can reduce food intake by nearly 50% within 12 hours in mice on a high-fat diet, without affecting their activity or energy expenditure [12]. - The study found that Lac-Phe levels significantly increase after exercise in both horses and humans, with the highest levels observed after sprinting, followed by resistance training and endurance training [13]. Group 2: Implications for Health - Regular exercise has been shown to aid in weight loss, appetite regulation, and metabolic improvement, particularly for overweight and obese individuals [10]. - The research suggests that understanding the molecular mechanisms behind exercise-induced health benefits could lead to new drug developments for individuals unable to exercise sufficiently, such as the elderly or frail patients [10][16]. - The findings reinforce the notion that exercise acts as a "medicine," promoting the production of Lac-Phe to suppress appetite and control weight, which is crucial in combating obesity-related health risks [16].