Cell：树突状细胞调控淋巴结中先天免疫-适应性免疫平衡，实现最佳宿主防御

Core Viewpoint - The research highlights the role of dendritic cells (DC) in regulating the balance between innate and adaptive immunity in lymph nodes, which is crucial for optimal host defense [2][4]. Group 1: Research Findings - Dendritic cells drive the rapid and polarized recruitment of innate effector cells to lymph nodes [4]. - This innate cell infiltration aids in controlling pathogens but limits the adaptive immune response [4]. - Dendritic cells and monocytes clear neutrophils to restore tissue structure and adaptive immune function [4]. - Dendritic cells act as a regulator, balancing the innate and adaptive immune functions in lymph nodes [4]. Group 2: Mechanisms and Processes - Following infection or vaccination, lymph node structures undergo rapid remodeling, with neutrophils and monocytes being recruited from inflammatory blood vessels [3]. - Dendritic cells facilitate this process by expressing inflammatory chemokines and integrin ligands [3]. - After the threat of infection is resolved, dendritic cells and recruited monocytes phagocytize neutrophils, thereby restoring the tissue architecture and creating conditions for the activation of downstream adaptive immune cells [3].