Nature Aging：陆新江/方马荣/冯晔/杨巍合作揭示炎症性衰老治疗新靶点——PIEZO1

Core Viewpoint - The research published in Nature Aging reveals that PIEZO1 can sense shear stress in blood flow, inducing hematopoietic stem cell (HSC) proliferation and myeloid differentiation, with implications for understanding inflammation-induced aging [2][5]. Group 1: Research Findings - The study identifies that shear stress affects both mouse and human HSCs through PIEZO1-mediated ion flow and calcium influx, regulated by the JAM3 and CAPN2 signaling pathways [5]. - The use of PIEZO1 antagonist GsMTx4 can inhibit HSC activation, thereby alleviating inflammation-induced aging in mice [5]. - These findings link the mechanical sensor PIEZO1 to HSC proliferation and myeloid differentiation, highlighting its critical role in accelerating inflammation-induced aging processes [5].