Nature子刊：华东理工大学刘润辉团队利用可自组装成递送胶束的宿主防御肽模拟物，实现组合抗真菌治疗

Core Viewpoint - The article discusses a novel combinatorial antifungal therapy strategy that utilizes a host defense peptide mimic to enhance the efficacy of antifungal treatments against drug-resistant fungal infections [3][6]. Group 1: Current Clinical Treatment Strategies for Fungal Infections - Current antifungal treatments often rely on single drug therapies, which have shown limited effectiveness and high failure rates against resistant fungal strains [3]. - The mortality rate for systemic fungal infections remains high due to the limited variety of antifungal drugs and their differing distribution in the body [3]. Group 2: New Strategy Proposed by the Research - The research team from East China University of Science and Technology developed a polymer that mimics host defense peptides, capable of forming micelles for the co-delivery of antifungal agents [5]. - This polymer demonstrated a synergistic effect with the classic antifungal drug Amphotericin B (AmB), allowing for the encapsulation of AmB in micelles, which significantly reduces its toxicity and expands its therapeutic window [5]. - In mouse models of systemic candidiasis and cryptococcal meningitis, AmB micelles improved survival rates by 67%-100% compared to existing treatments, indicating potential effectiveness against drug-resistant fungal infections [5].