2025年度盘点 | 国内合成生物学领域Nature子刊论文

Core Viewpoint - The article highlights significant advancements in the field of synthetic biology in China, showcasing 18 high-quality research papers published in Nature sub-journals in 2025, reflecting the country's research strength and innovation level in this domain [2]. Group 1: Research Highlights - A study published in Nature Sustainability presents a tandem electro-biosystem that upgrades surplus acetone from the phenol industry into high-value long-chain chemicals, achieving nearly 100% conversion to pure isopropanol (IPA) [3][38]. - Research in Nature Biotechnology introduces a microchip-based massively parallel DNA synthesis system, significantly increasing the concentration of synthetic products and improving assembly success rates by 4-6 orders of magnitude [4][6]. - Another Nature Biotechnology paper discusses a plug-and-play system for producing scalable secondary metabolites in Streptomyces, achieving a titration of 8.4 g/L for a specific antibiotic in industrial fermentation [7]. Group 2: Innovative Techniques - A study in Nature Catalysis reveals a new catalytic route using small molecule reductants for haem peroxygenases, avoiding irreversible enzyme inactivation and demonstrating high production rates of valuable chiral products [10]. - Research in Nature Synthesis introduces an iMECS strategy for the efficient conversion of lignin into various additive-type natural products, achieving a conversion rate exceeding 90% without external cofactors [12][17]. - A dual-channel energy pathway combining energy molecule supply and electron transfer in an E. coli-thylakoid hybrid system is reported, significantly enhancing hydrogen production rates [15]. Group 3: Applications and Implications - The development of an artificial ocean carbon cycling system is presented in Nature Catalysis, which captures CO2 from seawater and converts it into bioplastic monomers, contributing to sustainable material production [11]. - A study in Nature Chemical Biology outlines a programmable biological communication system between distinct membraneless compartments, providing insights into cellular interactions and potential applications in synthetic biology [23][26]. - Research on engineered spores for producing biodegradable living plastics demonstrates a novel approach to sustainable material development, with potential applications in environmental conservation [31][35].