Cell子刊：杨仕明/唐波/孙碧韶团队揭示高海拔环境通过肠道菌群抑制精子生成

Core Findings - High altitude exposure leads to gut microbiome imbalance, resulting in decreased sperm quality [5] - Increased levels of C. symbiosum produce succinic acid, which damages sperm quality [5] - Succinic acid activates the GPR91/TRPV4/Ca2+ signaling pathway in testicular macrophages, promoting the polarization of these cells [5][4] - The polarization of macrophages induced by succinic acid increases apoptosis of spermatogenic cells [5] Mechanism Insights - The study reveals that high altitude induces changes in the gut microbiome, specifically an increase in C. symbiosum, which negatively impacts sperm quality [4] - Succinic acid acts on G protein-coupled receptor GPR91, leading to the activation of TRPV4/Ca2+ signaling in testicular macrophages, resulting in inflammatory polarization [4][5] - The impact of C. symbiosum or succinic acid on sperm quality is dependent on TRPV4 signaling [4] Implications for Treatment - The research suggests potential therapeutic pathways based on gut microbiome modulation to address altitude-induced sperm damage [7]