北京大学医学部发表甘油二酯研究：有效降低内脏脂肪及缺血性脑卒中风险，或成中国人群健康膳食管理新策略

Core Viewpoint - Cardiovascular diseases are a major public health challenge in China, with a high mortality rate and increasing prevalence among younger populations. The study highlights the importance of exploring fat control solutions that align with Chinese cooking habits, particularly focusing on the use of diacylglycerol (DAG) oil as a healthier alternative to traditional triglyceride (TAG) oil [3][4]. Group 1: Research Findings - A recent study published in the journal "Food & Function" by a team from Peking University Medical School demonstrated that replacing traditional TAG oil with DAG oil in daily diets significantly improves lipid metabolism in the Chinese population [4][6]. - The study involved 120 Chinese adults with a BMI of 25.93±2.92 kg/m², who were randomly assigned to either the DAG group or the TAG group for an 8-week dietary intervention. Results showed that the DAG group had significantly lower serum triglycerides (TG), total cholesterol (TC), and small dense low-density lipoprotein cholesterol (sdLDL-C) levels compared to the TAG group [6][9]. - Notably, the DAG group experienced a significant reduction in visceral fat area (VFA) and improvements in liver fat degeneration, indicating potential benefits for non-alcoholic fatty liver disease [6][9]. Group 2: Clinical Significance - The study is the first to systematically validate the effects of DAG oil on key lipid indicators in the Chinese population, particularly its ability to lower sdLDL-C, which is a strong predictor of atherosclerosis and ischemic stroke [7][9]. - The research emphasizes the multi-mechanism benefits of DAG, highlighting its role in reducing visceral fat, which is a core risk factor for metabolic syndrome, type 2 diabetes, and cardiovascular diseases [9][14]. - Lipidomic analysis revealed that DAG intervention led to significant increases in triglycerides and phosphatidylethanolamine rich in monounsaturated and polyunsaturated fatty acids, which are associated with the activation of fat breakdown and thermogenesis pathways [11][14]. Group 3: Implications for Public Health - The findings fill an important evidence gap regarding the health effects of DAG oil in the Chinese population, aligning with the dietary habits of "no oil, no dish" prevalent in Chinese cooking [14]. - Promoting the use of DAG oil represents a practical health choice that does not require changes in cooking habits, potentially improving metabolic health and reducing cardiovascular risks simply by switching oils [14].