南方科技大学发表最新Science论文

Core Viewpoint - The article discusses a novel pericyclic reaction called triatropic rearrangement, which allows for high selectivity in editing saturated carbon ring frameworks, providing new pathways for the precise editing of complex cyclopentane and natural product scaffolds [4][6]. Group 1 - The research was conducted by Associate Professor Dong Zhe and Assistant Professor Yu Peiyuan from Southern University of Science and Technology, and published in the prestigious journal Science [3]. - The triatropic rearrangement reaction simultaneously breaks three σ bonds and forms two σ bonds and one π bond in a single transition state, enabling stereoselective transformations of carbon-oxygen bonds in epoxides into carbon-carbon bonds [5]. - This strategy allows for highly selective carbon migration reactions in epoxidized cycloalkanes, generating cyclized products with high chemical, regio-, and stereoselectivity [5]. Group 2 - The triatropic rearrangement reaction can be modularly combined with classical reactions, offering a unique "[4+2–1]" strategy for constructing complex cyclopentanes [5][6]. - The research highlights the broad applicability and high stereocontrol of the triatropic rearrangement, making it a significant advancement in synthetic chemistry [4][6].