中年减肥为何格外艰难？《Science》揭示：年龄增长使脂肪细胞激增5倍，代谢失衡、慢性疾病接连袭来！

Core Viewpoint - The article discusses the biological mechanisms behind weight gain in middle age, particularly focusing on the role of a specific type of fat precursor cell, CP-A, which becomes more active with aging and contributes to abdominal fat accumulation [7][12][24]. Group 1: Mechanisms of Weight Gain - Traditional views suggest that fat cell numbers remain constant after adulthood, with weight gain primarily due to the enlargement of existing fat cells. However, recent studies indicate that new fat cells are generated in significant numbers, especially in middle age [9][10]. - Research on mice shows that as they reach middle age (approximately 9-12 months), the number of new fat cells generated in the visceral fat area significantly increases compared to younger mice [10]. Group 2: Role of CP-A Cells - The study identifies CP-A cells, a specific type of fat precursor cell, as a major contributor to fat accumulation in middle age. These cells become dominant in visceral fat tissue as aging progresses [12][15]. - In young mice, CP-A cells are nearly absent, but they rapidly increase in number in middle-aged mice, comprising 34.23% of the visceral white fat tissue [15]. Group 3: Mechanisms of CP-A Cell Activity - CP-A cells exhibit enhanced proliferation and differentiation capabilities, with their proliferation rate being 2.5 times that of young fat precursor cells. They also show a fourfold increase in the ability to generate new fat cells compared to similar cells from younger mice [17][19]. - The article highlights that even in a young mouse environment, CP-A cells can produce five times more fat cells than their younger counterparts [19]. Group 4: Potential Interventions - The LIFR (leukemia inhibitory factor receptor) signaling pathway is identified as a potential target for intervention. High expression levels of LIFR in CP-A cells suggest it plays a crucial role in their proliferation and fat generation [20][23]. - Experiments show that inhibiting LIFR significantly reduces fat generation in CP-A cells while having little effect on young fat precursor cells, indicating a unique dependency of CP-A on LIFR signaling [22][24]. Group 5: Conclusion - The increase in visceral fat in middle age is attributed not just to metabolic issues but to the proliferation of new fat cells, particularly CP-A cells. Targeting LIFR may offer a new strategy to combat stubborn abdominal fat in middle-aged individuals [24][25].