如果使用司美格鲁肽疗效不佳，自查这四大因素是否影响减肥进程！

Core Viewpoint - The article discusses the challenges and individual variability in the effectiveness of GLP-1 medications for weight loss, highlighting that a significant portion of patients may not achieve desired results due to various factors such as genetic differences, lifestyle habits, and medication adherence [2][4]. Group 1: Individual Variability in Weight Loss - Approximately 10%-15% of patients using GLP-1 medications experience poor weight loss results, with less than 5% weight reduction [4] - In clinical trials, about 14% of participants using semaglutide did not achieve a 5% weight loss, and one-third lost less than 10% [4] - Genetic differences and prior medication history may contribute to the variability in weight loss outcomes among patients [4] Group 2: Dosage and Administration - Individual sensitivity to GLP-1 medications necessitates careful dosage adjustments, starting with 0.25mg weekly and potentially increasing to 2.4mg based on efficacy and tolerance [5] - Adjustments in dosage should be made under medical supervision, considering individual health conditions [7] Group 3: Lifestyle Factors - Weight loss is not solely dependent on medication; lack of resistance training and high protein intake can hinder results [8] - A comprehensive approach combining medication with lifestyle changes, such as diet and exercise, is essential for effective weight management [8] Group 4: Weight Loss Plateaus - Weight loss plateaus are common due to a decrease in basal metabolic rate after losing approximately 5 kg [9] - The body may enter an energy conservation mode, making it difficult to continue losing weight [9] - Strategies to overcome plateaus include increasing metabolic rate and adjusting dietary habits [11][12] Group 5: Importance of Sleep - Insufficient sleep can disrupt metabolic regulation, leading to increased hunger and decreased satiety, which may hinder weight loss efforts [13] - Adequate sleep (7-9 hours per night) is crucial for muscle recovery and overall health, supporting weight loss and body composition goals [13] Group 6: Counterfeit Drug Concerns - The rise of counterfeit semaglutide drugs poses significant risks, with illegal production and sales reported in multiple regions [14] - Consumers are advised to purchase medications only from licensed pharmacies and under medical guidance to avoid potential health hazards [14]