Cell Res封面论文：邹卫国/乐融融团队发现感知损伤炎症以协调骨折修复的骨外膜干细胞亚群

Core Viewpoint - The article discusses the significant role of periosteal stem cells in bone fracture repair, highlighting their unique properties and the mechanisms behind their activation during injury [5][11]. Group 1: Bone Healing Mechanisms - Bone healing typically follows a process reminiscent of embryonic cartilage development, but the cellular basis and regulatory mechanisms of normal and impaired healing remain unclear [3]. - Periosteal stem cells are crucial for bone development and homeostasis, yet they exhibit high heterogeneity in function and location within different microenvironments [4]. Group 2: Research Findings - A study published in Cell Research identified a specific group of resting periosteal stem cells expressing Angptl7, which are primarily responsible for fracture repair through endochondral ossification [5]. - The research revealed that Angptl7+ cells do not contribute to bone formation under normal conditions but become activated during fracture healing, indicating a specialized role in tissue repair [10]. Group 3: Cellular Heterogeneity - The study utilized single-cell transcriptome sequencing to uncover the heterogeneity of periosteal stem cells, identifying two distinct subpopulations: one expressing Angptl7 and another expressing Postn, with different roles in bone maintenance and repair [8][9]. - Angptl7 cells are associated with stem cell maintenance, while Postn cells are linked to osteogenic differentiation and bone formation [8]. Group 4: Implications for Future Research - The findings provide insights into the cellular basis of efficient bone repair and propose a novel model of tissue repair involving resident stem cells dedicated to injury response [5][11]. - The research establishes a specific lineage tracing mouse model for periosteal cells, which can aid in exploring the molecular mechanisms behind impaired fracture healing and developing new therapeutic strategies [11].